Penetration through mucous membranes - Mavi 2012

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Penetration through mucous membranes

Health Area > Dermatology

Mucous membranes are highly specialized ephitelial tissues, totally different from the skin that shares the interest of gynaecologists, dermatologists, cytologists and genito-urinary surgeons.
There are three main differences between mucosal surfaces and body skin.
The first is the fact that the former is generally covered by a protective and lubrificant mucus over its surface whilst the skin produces continuous  and impermeable lipid-filled keratin layers which vary from site to site, and are not modifiable by the presence of the surface lipids film. The second major difference is the sensivity of mucous membranes to circulating hormones, whereas human skin is virtually unaffected by androgenic or aestrogenic hormones until old age is reached. The third different of mucous membranes is their turnover rate which is much greater than that of the skin epidermis. Because of the continous presence and activity of mucus even the keratinized zones of mucous ephitelium  are maximally hydrated and therefore would be expected to show  an incresead permeability to water compared with body skin. Thus it was recognized that the lipid-filled, intercellular domains is crucially important to barrier function of the skin, such as mucus performs the  barrier function of mucous membranes.
For these reasons, cosmetic raw materials and active ingredients used can move through epithelia by simple diffusion, endocytosis or by active transport across membranes for obtaining a real cosmetic diffusion system.
It is of atmost importance the chemical and physical nature of the penetrating selected active ingredients in relation to its movement through the vaginal mucous membranes. In general, ions have more difficulty in penetrating than molecules, but small  molecules, such as glycine or vitamin A, penetrate more easily than larger molecules.
Thus, the degree of ionization of an active substance will affect the rate at which it penetrates, and this is often dependent upon the pH. Moreover generally speaking, the permeability of mucous membrans is similar to that of fully hydrated body skin.
After the evaluation of all these parameters vehicle has been developed for mucous membranes: the Mavi Diffusion System® (MDS),
It  was studied on purpose to amiliorate and to facilitate the absorption of  the active raw materials  therefore for the vehicle formulation of gynecological products have been selected specific macromolecules which have a structure compatible with the molecules of the mucus glycoprotein, thus enabling them to enter the environment of the mucus layer.
Moreover this vehicle used allowing also smaller active molecules to interchange between the living epithelial cells and their surroundings. Thus, depending on their molecular size and ionic charge. This is the reason of the patented use of gelatin-glycine and/or gelatin-arginine, or gelatin-cystine necessary for enhancing both the hydration of mucus membranes and penetration rate of the active compounds. Because of this all the componets of MDS are miscible with  mucus and migrate to the outer surface of the mucus where they form a monolayer with the mucus-like portion of their molecules in the mucus phase and the other portion protruding into the surrounding medium. These may be the reasons of the demonstrated  clinical activity of some gynaecological cosmetics such as Elageno A  Monodose or  Elageno A Gel.
They form an organized defensive barrier at the interface between the epithelia surface and its environment and mantain the normal pH values, protecting the underlying cells against bacterial and viral infections. Contemporary through out the activity of the vitamin A and PCA, Elageno A seems to stimulate or induce also the formation of mucoproteins and other mucus substances.


 
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