Mucous membranes are highly specialized ephitelial tissues, totally different from the skin that shares the interest of gynaecologists, dermatologists, cytologists and genito-
There are three main differences between mucosal surfaces and body skin.
The first is the fact that the former is generally covered by a protective and lubrificant mucus over its surface whilst the skin produces continuous and impermeable lipid-
For these reasons, cosmetic raw materials and active ingredients used can move through epithelia by simple diffusion, endocytosis or by active transport across membranes for obtaining a real cosmetic diffusion system.
It is of atmost importance the chemical and physical nature of the penetrating selected active ingredients in relation to its movement through the vaginal mucous membranes. In general, ions have more difficulty in penetrating than molecules, but small molecules, such as glycine or vitamin A, penetrate more easily than larger molecules.
Thus, the degree of ionization of an active substance will affect the rate at which it penetrates, and this is often dependent upon the pH. Moreover generally speaking, the permeability of mucous membrans is similar to that of fully hydrated body skin.
After the evaluation of all these parameters vehicle has been developed for mucous membranes: the Mavi Diffusion System® (MDS),
It was studied on purpose to amiliorate and to facilitate the absorption of the active raw materials therefore for the vehicle formulation of gynecological products have been selected specific macromolecules which have a structure compatible with the molecules of the mucus glycoprotein, thus enabling them to enter the environment of the mucus layer.
Moreover this vehicle used allowing also smaller active molecules to interchange between the living epithelial cells and their surroundings. Thus, depending on their molecular size and ionic charge. This is the reason of the patented use of gelatin-
They form an organized defensive barrier at the interface between the epithelia surface and its environment and mantain the normal pH values, protecting the underlying cells against bacterial and viral infections. Contemporary through out the activity of the vitamin A and PCA, Elageno A seems to stimulate or induce also the formation of mucoproteins and other mucus substances.